originally described to occur with the earliest return of lymphocytes to the peripheral circulation of patients with acute leukemia after marrow ablative therapy (i.e. in patients who did not receive a marrow transplant)
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rash = exanthematous; ddx – drug eruption, viral exanthems
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an acute elevation of temperature accompanied the cutaneous eruptions
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resolution of the eruption occurred with multi-line hematological recovery
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histology – non-specific changes (but no significant epidermal cell necrosis vs. GVHD)