By Disease Name > Erythema Elevatum Diutinum

Erythema Elevatum Diutinum

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red (erythema), raised (elevatum), with a strong tendency toward persistence (diutinum) rather than toward involution
rare;  distributed acrally and symmetrically over extensor surfaces (trunk generally spared)
histology = LCV
pathogenesis:  most likely caused by immune complex deposition (Arthus reaction)
associated IgA monoclonal gammopathy ?
treatment:  dramatic response to dapsone or sulfapyridine (sulfones are suppressive not curative and exacerbations are more severe with each subsequent withdrawal of meds)

 

ddx:

Sweets syndrome: distinguished by character and distribution of lesions, and no LCV on histology
granuloma faciale: (a histologic not clinical ddx)  less vascular involvement, more eosinophils and strict regular sparing of the overlying epidermis