Disease:

Antigen:

Intraepidermal:

SPD (“classic”)??

(-)

Pemphigus

(all variants except…)

IgA pemphigus

Paraneoplastic pemphigus

Subepidermal:

bullous pemphigoid

BP1 (230kd), BP2 (180kd)

EBA

collagen VII (290kd)

cicatricial pemphigoid

variable

herpes gestationis

BP 2 (180kd)

dermatitis herpetiformis

smooth muscle cell endomysium

Linear IgA

variable:

roof = 97kd (part of BP2)

floor = type VII collagen

Bullous SLE

type VII collagen