| • | a group of heterogenous disorders having in common a distinctive histopathologic structure |
| • | risk of malignant degeneration: higher in variants with larger, chronic lesions; much lower in DSAP |
| • | at least 4 clinical forms: |
Porokeratosis of Mibelli
| • | autosomal dominant or sporadic |
| • | pathognomonic sign = “the Great Wall of China” |
Disseminated superficial actinic porokeratosis (DSAP)
| • | during summer, lesions may become more erythematous and hyperkeratotic |
| • | predominantly sun-exposed sites; especially legs |
| • | no evidence of skin cancer arising (in one large study) |
| • | tx: 5-FU, cryotherapy, or topical retinoids |
Porokeratosis palmaris et plantaris
| • | autosomal dominant; rare |
Linear porokeratosis
|