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Triads

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Some diseases have a classic triad of symptoms or signs (e.g. Reiter's disease).  And sometimes it is just useful to quiz yourself by covering the disease and naming three bullet points about each disease listed below.  You can't know "everything" about every disease, but if you distill each disease down to a triad of important features, things become more manageable:

Anhidrotic Ectodermal Dysplasia

1.hypotrichosis
2.anodontia
3.hypohidrosis to anhidrosis

Antiphospholipid Antibody Sx

1.thrombosis (arterial or venous)
2.fetal  loss (recurrent)
3.thrombocytopenia

Basal Cell Nevus Syndrome:

1.several basal cell carcinomas at a young age
2.jaw cysts (odontogenic keratocysts)
3.palmoplantar pits

Behçet’s disease:

1.oral aphthae
2.genital ulceration
3.posterior uveitis

Bloom Syndrome:

1.telangiectatic malar erythema
2.photosensitivity
3.dwarfism

Dyskeratosis congenita:

1.nail dystrophy
2.oral leukoplakia
3.poikiloderma (that results in reticulate hyperpigmentation)

Follicular occlusion triad:

1.hidradenitis suppurativa
2.dissecting perifolliculitis of the scalp
3.acne conglobata

Gardner’s syndrome

1.osteomas
2.epidermal cysts
3.colon polyps (prophylactic colectomy)

Hand-Schüller-Christian Disease

1.osteolytic bone lesions (geographic skull)
2.diabetes insipidus
3.exophthalmos

Henoch-Schonlein Purpura

1.purpura
2.arthritis
3.abdominal pain

Hidrotic Ectodermal Dysplasia

1.sparse hair
2.palmoplantar keratoderma
3.nail dystrophy

Melkersson-Rosenthal syndrome

1.cheilitis granulomatosa
2.recurrent facial nerve palsy
3.scrotal tongue

Muir-Torre syndrome

1.sebaceous tumors (sebaceous adenoma)
2.KA’s
3.GI malignancy (colon cancer)

Mycetoma

1.tumefaction
2.sinuses
3.granules

Netherton’s syndrome

1.ichthyosis linearis circumflexa
2.atopic diathesis
3.trichorrhexis invaginata

Ochronosis

1.cutaneous pigmentation (pigmented cartilage visualized through the skin)
2.dark urine (@ pH>7.0)
3.arthropathy (severe; large joints)

PXE

1.skin
2.eyes
3.blood vessels (claudication, HTN, GI hemorrhage)

Reiter’s syndrome

1.arthritis
2.urethritis (or diarrhea)
3.conjunctivitis

RMSF (in endemic areas)

1.fever
2.myalgia
3.headache

Sézary’s syndrome

1.erythroderma
2.lymphadenopathy
3.> 10-15% atypical mononuclear cells in peripheral blood

Sjogren’s syndrome

1.Keratoconjunctivitis sicca
2.Xerostomia
3.Positive rheumatoid factor

Sjögren-Larsson syndrome

1.ichthyosis
2.spastic diplegia (with scissor gait)
3.mental retardation

WG diagnostic triad

1.upper respiratory tract
2.lower respiratory tract
3.glomerulonephritis

Wiskott-Aldrich syndrome

1.atopic-like eczematous dermatitis
2.recurrent infections
3.thrombocytopenia

X-linked ichthyosis

1.dirty scale
2.spares flexures
3.comma-shaped corneal opacity