Basic Science / Structures > Basement Membrane > BP2 antigen (180kd)

BP2 antigen (180kd)

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mnemonic:  a transmembrane protein (therefore it spans many diseases)
BP and herpes gestationis aka "pemphigoid gestationis" and
cicatricial pemphigoid:  a disease with variable antigens  (but when the roof of the salt split lights up,  BP2 is often the antigen)
linear IgA disease:  variable antigens (but when the roof lights up, a 97kd antigen (identical to the extracellular portion of the BP2 antigen) is the target)
genetic mutation in BP180 = GABEB (generalized atrophic benign epidermolysis bullosa)