Basic Science / Structures > Dermis > Collagen Disorders

Collagen Disorders

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Ehlers-Danlos Syndromes

Osteogenesis Imperfecta

Scurvy = acquired defect in collagen metabolism

 

 

type I = reticular dermis

type II = cartilage only

type III = papillary dermis, fetal skin, blood vessels

type IV = basal lamina

type VII = anchoring fibrils

 

 

Collagen defect: Disease:

 

abnormal type I collagen osteogenesis imperfecta

 

antibodies vs. type II collagen Relapsing polychondritis

 

defect in type III procollagen Ehlers-Danlos type IV (arterial-ecchymotic)

 

abnormal type V collagenEhlers-Danlos type I or II

 

antibodies vs. type VII collagen EBA/ bullous SLE

 

defect or absence of type VII collagen dystrophic EB