Differential Diagnosis > Morphology > Reaction Patterns > Vesicobullous > Intraepidermal

Intraepidermal

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hmtoggle_plus1Infectious:
•herpes simplex; herpes zoster; varicella
•rickettsial pox  (more “crusts” than blisters)
•hand, foot, and mouth disease
•impetigo; bullous impetigo; staph scalded skin
•candida
•congenital syphilis
•scabies (neonates only)

 

hmtoggle_plus1Spongiotic:
•contact dermatitis (acute)

 

hmtoggle_plus1Pemphigus:
•pemphigus (vulgaris, foliaceous,and paraneoplastic)
•Hailey-Hailey (aka benign familial pemphigus)

 

 

coma blisters (spans the categories: may be intra OR subepidermal)