| • | Tense blisters may become flaccid, but flaccid blisters never become tense (therefore when both are present, it is sub-epidermal blistering disease) |
| • | Cannot differentiate between intraepidermal and subepidermal at acral areas because stratum corneum is thick, therefore all appear to be tense. |
| • | milia with blistering disease = subepidermal (pieces of epidermis get stuck in dermis and they encyst) |
| • | see also Basic Science - Basement Membrane |
It is useful to think of all sub-epidermal blistering diseases when you see tense blisters. These consist of the pemphigoid group, the IgA group, and others:
Subepidermal Bullae
|
coma blisters and bullous diabeticorum (span the categories: may be intra or subepidermal)