Therapy > Medication > Ketoconazole

Ketoconazole

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mnemonic:  “knee-“ zoral (the side effects are a proverbial "knee to the testes")
must take with food;  QD oral drug

 

Toxicity:

inhibits the cytochrome P-450 system, which is important in testosterone synthesis
therefore, gynecomastia, impotence, decreased libido, and decreased sperm production