| • | tender red macules, papules; often acrally several days after cytoreductive chemotherapy |
| • | resolve spontaneously within several days |
| • | possible mechanism is concentration of responsible agents in eccrine glands with resulting cytotoxicity |
| • | neutrophilic infiltrate surrounding and involving eccrine coils |
| • | epithelial cell vacuolar degeneration and necrosis |
| • | focal mucinous degeneration of peri-eccrine subcutaneous fat |
see: oncology patient, acral erythema ddx
see Toxic Erythema of Chemotherapy
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