| • | term proposed by Bolognia to encompass the constellation of cutaneous findings seen with chemotherapy |
Clinical:
| • | pruritic and painful erythematous plaques; lesions can be dusky and often vesiculate |
| • | the predilection for intertriginous and palmar skin may be related to excretion of chemotherapeutic agents via eccrine sweat and accumulation in glands and ducts |
| • | mucosal and GI involvement is common |
Timing:
| • | typically appears within 2 to 3 weeks of initiating chemo |
| • | with lower dose regimens a delayed reaction may be seen between 2 and 10 months after treatment begins |
Offenders:
| • | common inciting agents: methotrexate, cytarabine, 5-FU, taxanes, capecitabine, anthracyclines |
Treatment:
| • | Treatment is supportive until the eruption spontaneously resolves |
| • | dose reduction of subsequent courses of chem may reduce severity |
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