By Disease Name > Squamous Cell Carcinoma

Squamous Cell Carcinoma

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•those arising in actinic keratosis = less aggressive (0.5% mets)
•those arising in scars or mucous membranes = more aggressive (20% metastasize)
•otherwise (2% mets)
•the p53 mutations induced by UV radiation are found in >90% of human SCC’s and are present in AK’s.

 

pearl - VORICONAZOLE: a drug used in transplant patients; can induce multiple aggressive SCC's (discontinuing the drug makes them easier to manage)